Females are significantly more likely to become addicted to nicotine as demonstrated by studies reporting that women have greater difficulty quitting smoking compared to men. Intensive research focuses on nicotinic acetylcholine receptors as the agents responsible for nicotine addiction. However, the mechanism by which females are more susceptible to nicotine dependency is not fully understood. In order…
BRODERICK BRAIN TEASER AWARD_Acquisition International Global and Corporate America Business Woman Elite
Studies of oxidative stress mechanisms using a morphine – ascorbate animal model and novel N-stearoyl cerebroside and laurate sensors by P. A. Broderick Summary. The field of oxidative stress, free radicals, cellular defense and antioxidants is a burgeoning field of research. An important biomarker of oxidative stress is ascorbate and alterations in ascorbate have been shown…
Temporal synchrony, discovered in our laboratory using Live Imaging, Neuromolecular Imaging (NMI), and the BRODERICK PROBE® reveals a distinctive rhythmic regularity between neurotransmitter synaptic release and movement frequency in the natural, physiologic state. Using this innovative nanotechnology of NMI and BRODERICK PROBE® nanobiosensors, a point-by-point temporal synchrony was imaged between the synaptic concentration of serotonin (5-HT) released from structures such…
Imaging White Matter Signals in Epilepsy Patients We studied 15 temporal lobe epilepsy patients who presented with either neocortical or mesial temporal lobe epilepsy. Resected tissue from these patients was studied with neuromolecular imaging (NMI) using miniature carbon-based BRODERICK PROBE® stearic and lauric acid sensors. In separate studies, a sensor was inserted into neocortex or hippocampus, specifically into individual…
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Nimodipine Reverses the Hypoxic Elevation of Serotonin and Tryptophan in the Striatum of Adult Rats. Michael M. Haile, M.D., Patricia A. Broderick, Ph.D., Yong-Sheng Li, M.D., David Quartermain, Ph.D., Thomas J.J. Blanck, M.D., Ph.D., Alex Y. Bekker, M.D., Ph. D., Department of Anesthesiology, NYU Langone Medical Center, Department of Physiology & Pharmacology, CUNY Medical School…
